Friend or Foe? The fascinating Tudor-SN protein

Tudor-SN (Tudor staphylococcal nuclease), also known as p100 or SND1 (Staphylococcal nuclease and Tudor domain containing 1), is a structurally conserved protein with diverse functions. Emerging evidence indicates that plays an essential role in both physiological pathological processes. Under conditions, regulates DNA transcription, RNA splicing, stability, interference, editing, it for series of cellular biological events, such cell cycle progression, metabolism, survival, response to harmful stimuli; thus, functions “friend” the body. However, highly expressed most tumor cells. As oncoprotein, closely associated initiation, development, metastasis tumors; “foe” What potential mechanism by which switches from its “foe”? In this study, we review summarize available regarding structure, expression, modification, mutation present novel model switching. This provides comprehensive insight into functional significance under conditions well corresponding therapeutic strategies target Tudor-SN.